Marketing Challenges Continue for Ultrasound Contrast Media
Nov. 20, 2004
Ultrasound contrast agents have great potential but are currently underutilized because of poor user education and high price relative to current procedure cost.
There are three approved ultrasound contrast agents. Optison (originally
developed by Molecular Biosystems) is licensed to Amersham; Definity
(developed by Imarx) is licensed to Bristol-Myers Imaging and Imagent
(developed by Alliance Pharmaceutical, now IMCOR Pharmaceutical).
All of these agents are approved for similar indications, i.e., opacification
of the left ventricle to delineate wall motion more effectively in
equivocal echocardiography cases. Manufacturers of these agents are
hopeful that indications will eventually be expanded to include cardiac
perfusion, where the market prospects are large. They are also hopeful
that radiology indications will be approved, augmenting visualization
of organs such as kidney and liver. While the market potential obviously
exists, more effort is required to convince both the users and FDA
of these opportunities.
One challenge is how to make the use of contrast agents part of the imaging protocol up front, rather than as an afterthought based on reviewing an inconclusive image. This is an educational process involving both clinicians and sonographers who need to be convinced of the effectiveness of this modality. Patient selection is obviously very important. Certain patients may benefit more from enhanced ultrasound than others. For example, heavy patients that are difficult to image because of attenuation of the ultrasound beam, may offer more opportunity for enhancement of the signal when using contrast agents.
Ultrasound equipment manufacturers also need to be brought into the loop to help optimize equipment performance with contrast agents. Their present disposition is that ultrasound works quite well on its own without contrast. Therefore, some inducement is necessary to get them to optimize equipment design around contrast agents. A critical mass of users is probably necessary to convince manufacturers that a market opportunity exists sufficient to justify the necessary investment.
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